Rewriting GPCR Drug Discovery with AI -Designed Biologics
At Skape Bio, we build biotherapeutics from scratch by combining de novo design and high-throughput screening to create new medicines
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Target Class:
GPCRs
Ion Channels
In Progress
Transporters
In Progress
GPCRs control the body’s most important signals and power medicine’s largest drug market.
A closed-loop platform for designing functional GPCR biologics at scale.
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Design
Biologics custom built for recessed GPCR pockets, dynamic receptor states and precise signalling control
Screen
Proprietary screening platform that tests up to 100,000 designs directly on full-length receptors in living human cells
Validate
In-house production, pharmacology, biophysics and DMPK tuning move hits into differentiated programs
Modality
Miniproteins
Nanobodies
In Progress
Antibodies
In Progress
Next-Gen Biologics With Proven Properties
Functionally Programmed
Built to control receptor signalling, creating agonists, antagonists and modulators.
Precise Targeting
Designed to reach hard-to-access parts of the receptor and lock onto the specific function we want.
Tunable Drug Properties
Compact, stable architectures optimized for half-life, tissue exposure and route of delivery.
Developable
Engineered for efficient production, purification and optimization to accelerate progression from hit to therapeutic program.
